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Santo Domingo to Medellín Flights — Fares from $598.00 | SDQ–MDE

Compare the cheapest Santo Domingo (SDQ) to Medellín (MDE) fares found by our live flight search, then book online or over the phone with our travel experts.

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Adults
12+
1
Children
2–11
0
Infants
Under 2
0
Cabin
🏷️
Save up to 40% with unpublished phone fares
Consolidator deals on selected Santo Domingo → Medellín flights that do not appear in online search results. The live fares below are bookable right now — or call to check for an unpublished fare on your dates.
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One-way fares Santo Domingo → Medellín

showing indicative fares · loading live prices…
DM Airlines
DM Airlines CHEAPEST
SDQ → MDE · Economy
lowest fare seen on this route
$997.32
$598.39
Select
Copa Airlines
Copa Airlines
SDQ → MDE · Economy
lowest fare seen on this route
$2,571.62
$1,542.97
Select
American Airlines
American Airlines
SDQ → MDE · Economy
lowest fare seen on this route
$3,503.40
$2,102.04
Select
Aeromexico
Aeromexico
SDQ → MDE · Economy
lowest fare seen on this route
$4,709.44
$2,825.66
Select
JetBlue
JetBlue
SDQ → MDE · Economy
lowest fare seen on this route
$29,843.40
$17,906.04
Select
See all flights & times → Prices per adult, one way, incl. taxes & fees. Availability changes constantly.
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Live fares we can book on SDQ–MDE

Lowest fare found per airline on the SDQ → MDE route, with our discounted phone-deal price.

AirlineCabin Found fareOur discounted fare Fare found on
DM Airlines DM Airlines Economy $997.32 $598.39 Aug 14, 2026 Book
Copa Airlines Copa Airlines Economy $2,571.62 $1,542.97 Aug 14, 2026 Book
American Airlines American Airlines Economy $3,503.40 $2,102.04 Aug 14, 2026 Book
Aeromexico Aeromexico Economy $4,709.44 $2,825.66 Aug 14, 2026 Book
JetBlue JetBlue Economy $29,843.40 $17,906.04 Aug 14, 2026 Book

Discounted fares are negotiated phone deals from our vendor network and may not appear in online search results — call 765-995-0868 to lock one in. Fares were found on the dates shown, are per person in USD, and change with availability.

More routes we cover

Santo Domingo to Bogota Santo Domingo to Boston Santo Domingo to Cúcuta Santo Domingo to New York Santo Domingo to Panama City Beach Santo Domingo to San Juan Mexico City to Medellín Mexico City to Medellín Philadelphia to Medellín Punta Cana to Medellín Santiago to Medellín All routes →

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Page updated August 16, 2026 · fare data refreshed automatically from live flight searches.