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Medford to San Diego Flights — Fares from $371.00 | MFR–SAN

Compare the cheapest Medford (MFR) to San Diego (SAN) fares found by our live flight search, then book online or over the phone with our travel experts.

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Adults
12+
1
Children
2–11
0
Infants
Under 2
0
Cabin
🏷️
Save up to 40% with unpublished phone fares
Consolidator deals on selected Medford → San Diego flights that do not appear in online search results. The live fares below are bookable right now — or call to check for an unpublished fare on your dates.
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One-way fares Medford → San Diego

showing indicative fares · loading live prices…
United Airlines
United Airlines CHEAPEST
MFR → SAN · Economy
lowest fare seen on this route
$619.90
$371.94
Select
Alaska Airlines
Alaska Airlines
MFR → SAN · Economy
lowest fare seen on this route
$626.80
$376.08
Select
Delta Air Lines
Delta Air Lines
MFR → SAN · Economy
lowest fare seen on this route
$633.86
$380.32
Select
American Airlines
American Airlines
MFR → SAN · Economy
lowest fare seen on this route
$664.48
$398.69
Select
See all flights & times → Prices per adult, one way, incl. taxes & fees. Availability changes constantly.
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Live fares we can book on MFR–SAN

Lowest fare found per airline on the MFR → SAN route, with our discounted phone-deal price.

AirlineCabin Found fareOur discounted fare Fare found on
United Airlines United Airlines Economy $619.90 $371.94 Oct 15, 2026 Book
Alaska Airlines Alaska Airlines Economy $626.80 $376.08 Oct 15, 2026 Book
Delta Air Lines Delta Air Lines Economy $633.86 $380.32 Oct 15, 2026 Book
American Airlines American Airlines Economy $664.48 $398.69 Oct 15, 2026 Book

Discounted fares are negotiated phone deals from our vendor network and may not appear in online search results — call 1-856-513-6369 to lock one in. Fares were found on the dates shown, are per person in USD, and change with availability.

More routes we cover

Medford to Carlsbad Medford to Phoenix Medford to Santa Barbara Medford to Yakima Austin to San Diego Baltimore to San Diego Beijing to San Diego Boston to San Diego Dallas-Fort Worth to San Diego Dallas to San Diego All routes →

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Page updated October 15, 2026 · fare data refreshed automatically from live flight searches.